Article
Genome-wide association analysis of secondary imaging phenotypes from the Alzheimer's disease neuroimaging initiative study.
NeuroImage - 1 Feb 2017
Zhu Wensheng, Yuan Ying, Zhang Jingwen, Zhou Fan, Knickmeyer Rebecca C, Zhu Hongtu
Abstract excerpt
The aim of this paper is to systematically evaluate a biased sampling issue associated with genome-wide association analysis (GWAS) of imaging phenotypes for most imaging genetic studies, including the Alzheimer's Disease Neuroimaging Initiative (ADNI). Specifically, the original sampling scheme of these imaging genetic studies is primarily the retrospective case-control design, whereas most existing statistical...
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