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Article

Longitudinal analysis is more powerful than cross-sectional analysis in detecting genetic association with neuroimaging phenotypes.

PloS one - 1 Jan 2014

Xu Zhiyuan, Shen Xiaotong, Pan Wei

Abstract excerpt

Most existing genome-wide association analyses are cross-sectional, utilizing only phenotypic data at a single time point, e.g. baseline. On the other hand, longitudinal studies, such as Alzheimer's Disease Neuroimaging Initiative (ADNI), collect phenotypic information at multiple time points. In this article, as a case study, we conducted both longitudinal and cross-sectional analyses of the ADNI data with...

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Source

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Identifiers

PMID: 25098835
DOI: 10.1371/journal.pone.0102312
PMCID: PMC4123854

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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