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Article

Identification of Genetic Risk Factors Based on Disease Progression Derived From Longitudinal Brain Imaging Phenotypes.

IEEE transactions on medical imaging - 1 Mar 2024

Du Lei, Zhao Ying, Zhang Jianting, Shang Muheng, Zhang Jin, Han Junwei

Abstract excerpt

Neurodegenerative disorders usually happen stage-by-stage rather than overnight. Thus, cross-sectional brain imaging genetic methods could be insufficient to identify genetic risk factors. Repeatedly collecting imaging data over time appears to solve the problem. But most existing imaging genetic methods only use longitudinal imaging phenotypes straightforwardly, ignoring the disease progression trajectory which...

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PMID: 37847615
DOI: 10.1109/TMI.2023.3325380

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