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Exposure Duration Shapes the Hepatic Response to GenX: Divergent Acute and Chronic Transcriptomic Profiles Reveal Non-Monotonic Dose Effects and Increased Sensitivity in Human Liver Spheroids

2026-08-14

Abstract excerpt

Hexafluoropropylene oxide dimer acid (GenX), a replacement for legacy per and polyfluoroalkyl substances (PFAS), is increasingly detected in the environment, yet its chronic toxicity remains poorly characterized. Current safety assessments rely largely on short term, high dose studies that may not capture the biological consequences of long term, low dose exposure. To address this gap, we employed 3D human liver (...

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Literature Corpus work
348c66b1-ec82-5c1a-b736-3d51b0e1a51b
DOI
10.64898/2026.08.08.743693
Open publication

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Exposure Duration Shapes the Hepatic Response to GenX: Divergent Acute and Chronic Transcriptomic Profiles Reveal Non-Monotonic Dose Effects and Increased Sensitivity in Human Liver SpheroidsDOI 10.64898/2026.08.08.743693
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