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Comparative sensitivity of <i>in vitro</i> acute and chronic apical and transcriptomic points of departure for perfluorooctanoic acid in human vascular endothelial cells

2024-12-25

Abstract excerpt

In vitro human cell models and new approach methodologies offer valuable alternatives to animal testing, providing human-relevant data for chemical risk assessment. However, the impact of exposure duration and biological levels on the sensitivity of responses in human cells in vitro remains underexplored. In this study, we employed benchmark concentration modeling to derive and compare points of departure (PODs)...

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Literature Corpus work
f46739c9-b13b-5623-93ab-ce28f53d4cd9
DOI
10.1101/2024.12.24.628084
Open publication

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Comparative sensitivity of <i>in vitro</i> acute and chronic apical and transcriptomic points of departure for perfluorooctanoic acid in human vascular endothelial cellsDOI 10.1101/2024.12.24.628084
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