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Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes.

ALTEX - 1 Jan 2024

Tsai Han-Hsuan D, Ford Lucie C, Chen Zunwei, Dickey Allison N, Wright Fred A, Rusyn Ivan

Abstract excerpt

Per- and polyfluoroalkyl substances (PFAS) are chemicals with important applications; they are persistent in the environment and may pose human health hazards. Regulatory agencies are considering restrictions and bans of PFAS; however, little data exists for informed decisions. Several prioritization strategies were proposed for evaluation of potential hazards of PFAS. Structure-based grouping could expedite the...

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Environmental Pollutants
Hepatocytes
Induced Pluripotent Stem Cells
Myocytes, Cardiac
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Assessment

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PMID: 38429992
DOI: 10.14573/altex.2311031
PMCID: PMC11305846

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