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Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroids

28 Feb 2025

Abstract excerpt

Understanding the mechanisms by which environmental chemicals cause toxicity is necessary for effective human health risk assessment. High-throughput transcriptomics (HTTr) can be used to inform risk assessment on toxicological mechanisms, hazards, and potencies. We applied HTTr to elucidate the molecular mechanisms by which per- and polyfluoroalkyl substances (PFAS) cause liver perturbations. We contrasted...

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PMID: 40037795
DOI: 10.1093/toxsci/kfaf023

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