Article

Investigating the mode of action for liver toxicity and wasting-like responses produced by high dose exposures to longer chain perfluoroacid substances (PFAS) using high throughput transcriptomics

2024-03-06

Abstract excerpt

Single doses of perfluoro-n-decanoic acid (PFDA) cause wasting, a progressive loss of 30 to 50% body weight, increasing liver/body weight ratios, and death within several weeks (Olson and Andersen, 1983). Repeat high doses of perfluorooctane sulfonate (PFOS) produce a subset of these responses in rats and monkeys. The mode of action (MOA) of these wasting-like syndromes is not clear, nor is it understood if these...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df716f34-aacf-5103-8a17-7c38d194d100
DOI: 10.1101/2024.03.02.583129

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the mode of action for liver toxicity and wasting-like responses produced by high dose exposures to longer chain perfluoroacid substances (PFAS) using high throughput transcriptomicsDOI 10.1101/2024.03.02.583129Read

Investigating fatty liver disease-associated adverse outcome pathways of perfluorooctane sulfonate using a systems toxicology approach.Semantic proximity Read

Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroidsSemantic proximity Read

Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant ConcentrationSemantic proximity Read

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterizationSemantic proximity Read

PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read

High-throughput transcriptomics and benchmark concentration modeling for potency ranking of per- and polyfluoroalkyl substances (PFAS) in exposed human liver cell spheroidsSemantic proximity Read

Mining Public Toxicogenomic Data Reveals Insights and Challenges in Delineating Liver Steatosis Adverse Outcome PathwaysSemantic proximity Read

PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth—a translational research frameworkSemantic proximity Read

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized MiceSemantic proximity Read

Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammationSemantic proximity Read

Integrating high-throughput phenotypic profiling and transcriptomic analyses to predict the hepatosteatosis effects induced by per- and polyfluoroalkyl substances.Semantic proximity Read

Chronic exposure to PFAS triggers systems-level cellular reprogramming independent of their bioaccumulationSemantic proximity Read