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Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells

2 Mar 2023

Abstract excerpt

Per- and polyfluoroalkyl substances (PFASs) are omnipresent and have been shown to induce a wide range of adverse health effects, including hepatotoxicity, developmental toxicity, and immunotoxicity. The aim of the present work was to assess whether human HepaRG liver cells can be used to obtain insight into differences in hepatotoxic potencies of a series of PFASs. Therefore, the effects of 18 PFASs on cellular...

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Adipose Tissue and Metabolism
Microbial metabolism and enzyme function

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36864359
DOI: 10.1007/s00204-023-03450-2

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