Article

Dihydroxyacetone phosphate signals glucose availability to mTORC1

2020-06-21

Abstract excerpt

In response to nutrients, the mTOR complex 1 (mTORC1) kinase regulates cell growth by setting the balance between anabolic and catabolic processes. To be active, mTORC1 requires the environmental presence of amino acids and glucose, which provide the building blocks for the biosynthesis of most macromolecules. While a mechanistic understanding of amino acid sensing by mTORC1 is emerging, how glucose activates mTOR...

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Literature Corpus work: 347ab901-a20c-5ad0-ad7e-037bf11a00ec
DOI: 10.1101/2020.06.21.161927

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