Article
Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.
The Journal of biological chemistry - 20 Sept 2013
Chen Chien-Hung, Kiyan Vladimir, Zhylkibayev Assylbek A, Kazyken Dubek, Bulgakova Olga, Page Kent E, Bersimbaev Rakhmet I, Spooner Eric, Sarbassov Dos D
Abstract excerpt
Nutrients are essential for living organisms because they fuel biological processes in cells. Cells monitor nutrient abundance and coordinate a ratio of anabolic and catabolic reactions. Mechanistic target of rapamycin (mTOR) signaling is the essential nutrient-sensing pathway that controls anabolic processes in cells. The central component of this pathway is mTOR, a highly conserved and essential protein kinase...
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