Article
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
Nature medicine - 1 Feb 2020
Laperle A H, Sances S, Yucer N, Dardov V J, Garcia V J, Ho R, Fulton A N, Jones M R, Roxas K M, Avalos P, West D, Banuelos M G, Shu Z, Murali R, Maidment N T, Van Eyk J E, Tagliati M, Svendsen C N
Abstract excerpt
Young-onset Parkinson's disease (YOPD), defined by onset at <50 years, accounts for approximately 10% of all Parkinson's disease cases and, while some cases are associated with known genetic mutations, most are not. Here induced pluripotent stem cells were generated from control individuals and from patients with YOPD with no known mutations. Following differentiation into cultures containing dopamine neurons,...
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