Article

Effects of Non-Cardiac/Non-neurologic Surgery and Anesthesia on the CSF Proteome, and Modulation by the APOE Mimetic Peptide CN-105

2025-10-07

Abstract excerpt

<h4>Background</h4> Neuroinflammation is thought to contribute to postoperative central nervous system (CNS)-related complications, and the apolipoprotein E (APOE)-mimetic peptide CN-105 blocks neuroinflammation in animal models. Thus, here we examined postoperative cerebrospinal fluid (CSF) proteome changes and their modulation by CN-105. <h4>Objective</h4> To evaluate postoperative changes in the CSF proteome,...

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Literature Corpus work: e4b667c6-4a7d-5b9b-b8ff-7a83ee103799
DOI: 10.1101/2025.10.06.25337433

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