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Article

Atherosclerotic Plaque Instability and Rupture: Recommended Mouse Models to Empower Clinically Relevant Discoveries, Diagnostics, and Therapeutics.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2025

Noonan Jonathan, Cardoso Luis, Bobik Alex, Peter Karlheinz

Abstract excerpt

CLINICAL PROBLEM: Atherosclerotic plaque instability/rupture is the major driver of myocardial infarction and stroke, the leading causes of cardiovascular morbidity/mortality. However, the mechanisms leading to plaque rupture are poorly understood. This limits our ability to establish sensitive and diagnostic tools to identify plaques that are prone to rupture and to develop much-needed plaque-stabilizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40991721
DOI: 10.1161/ATVBAHA.125.321011
PMCID: PMC12483285

Genes

LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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