Article

Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques

2025-04-19

Abstract excerpt

<h4>Background and Aims</h4> Metabolism dictates macrophage function and plays a central role in atherosclerotic plaque progression. The kynurenine pathway, which metabolizes the majority of the essential amino acid tryptophan, plays a pivotal role in regulating immune responses and supporting NAD+ synthesis, essential for cellular energy metabolism. Higher circulating kynurenine levels are associated with cardio...

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Literature Corpus work: 343329ce-6f9f-589d-9363-30e93fa2dd1a
DOI: 10.1101/2025.04.14.648852

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