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Article

Polyunsaturated Fatty Acids Mend Macrophage Transcriptome, Glycome, and Phenotype in the Patients with Neurodegenerative Diseases, Including Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Dover Mary, Moseley Taylor, Biskaduros Adrienne, Paulchakrabarti Mousumi, Hwang Sung Hee, Hammock Bruce, Choudhury Biswa, Kaczor-Urbanowicz Karolina Elżbieta, Urbanowicz Andrzej, Morselli Marco, Dang Johnny, Pellegrini Matteo, Paul Ketema, Bentolila Laurent A, Fiala Milan

Abstract excerpt

BACKGROUND: Macrophages of healthy subjects have a pro-resolution phenotype, upload amyloid-β (Aβ) into endosomes, and degrade Aβ, whereas macrophages of patients with Alzheimer's disease (AD) generally have a pro-inflammatory phenotype and lack energy for brain clearance of Aβ. OBJECTIVE: To clarify the pathogenesis of sporadic AD and therapeutic effects of polyunsaturated fatty acids (PUFA) with vitamins B and...

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Identifiers

PMID: 36373322
DOI: 10.3233/JAD-220764
PMCID: PMC9881025

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