Article
Single-nucleus RNA sequencing reveals that macrophages and smooth muscle cells promote carotid atherosclerosis progression through mitochondrial autophagy
2023-05-31
Abstract excerpt
Objects Carotid atherosclerotic plaques are the manifestation of atherosclerosis in the carotid arteries and can significantly increase the incidence of cerebrovascular disease. Macrophages and smooth muscle cells are crucial for their development. Our research aimed to reveal the mechanism of carotid atherosclerotic plaque formation. Methods The collected carotid plaques were processed to extract RNA and create...
Topics
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- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Cerebrovascular and Carotid Artery Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- TGF-β signaling in diseases
Identifiers and source
- Literature Corpus work
- 970374eb-bbf4-51b5-9fc1-8848829921c6
- DOI
- 10.21203/rs.3.rs-2917007/v1
