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Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

14 Aug 2020

Abstract excerpt

BACKGROUND: The metabolism of tryptophan (Trp) along the kynurenine pathway has been shown to carry strong immunoregulatory properties. Several experimental studies indicate that this pathway is a major regulator of vascular inflammation and influences atherogenesis. Knowledge of the role of this pathway in human atherosclerosis remains incomplete. OBJECTIVES: In this study, we performed a multiplatform analysis...

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PMID: 32794238
DOI: 10.1111/joim.13142

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