Article
Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability.
Cardiovascular diabetology - 8 Jul 2024
Jin Han, Zhang Cheng, Nagenborg Jan, Juhasz Peter, Ruder Adele V, Sikkink Cornelis J J M, Mees Barend M E, Waring Olivia, Sluimer Judith C, Neumann Dietbert, Goossens Pieter, Donners Marjo M P C, Mardinoglu Adil, Biessen Erik A L
Abstract excerpt
BACKGROUND: Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular wall, including endothelial cells, smooth muscle cells, and inflammatory cells. However, a comprehensive analysis of metabolic changes associated with the transition of plaque from a stable to a hemorrhaged phenotype is lacking. METHODS: In this...
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