Article

A multi-scale <i>in silico</i> mouse model for insulin resistance and humanoid type 2 diabetes

2021-05-21

Abstract excerpt

Insulin resistance (IR) causes compensatory insulin production, which in humans eventually progresses to beta-cell failure and type 2 diabetes (T2D). This disease progression involves multi-scale processes, ranging from intracellular signaling to organ-organ and whole-body level regulations, on timescales from minutes to years. T2D progression is commonly studied using overfed and genetically modified rodents. How...

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Literature Corpus work: 59844e03-eac9-5ad7-a1a7-73288e3b2a3d
DOI: 10.1101/2021.05.19.443124

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