Article

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology

2025-02-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Nonsyndromic orofacial clefts (OFCs) involve complex genetic and environmental factors, with over 60 risk loci accounting for only a minority of estimated heritability and residing in non-coding regions with unclear functional relevance. We hypothesize that some genetic variants alter orofacial cleft risk by modifying DNA methylation (DNAm) at regulatory sequences essential...

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Literature Corpus work: 33b8884f-f251-5476-9aac-25b3a1f19d8c
DOI: 10.1101/2025.02.09.25321494

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