Article

Comprehensive analysis of <i>de novo</i> variants across 2,497 orofacial cleft trios reveals novel genetic drivers of disease

2026-05-24

Abstract excerpt

<h4>Background</h4> Orofacial clefts (OFCs) and other palate abnormalities (PAs) are among the most common birth defects worldwide and are characterized by the abnormal formation of the lip and/or palate. Genetic studies have traditionally classified OFC cases as either syndromic, involving OFCs alongside other congenital anomalies, or nonsyndromic, which represent the majority of cases and occur in isolation. Em...

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Literature Corpus work: b7d2db43-dbfd-59dd-bdba-aa8ce2ff3c51
DOI: 10.64898/2026.05.21.26352934

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