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Article

Distinct DNA methylation profiles in subtypes of orofacial cleft.

Clinical epigenetics - 1 Jan 2017

Sharp Gemma C, Ho Karen, Davies Amy, Stergiakouli Evie, Humphries Kerry, McArdle Wendy, Sandy Jonathan, Davey Smith George, Lewis Sarah J, Relton Caroline L

Abstract excerpt

BACKGROUND: Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environmental factors. Given the evidence that different subtypes of orofacial cleft have distinct aetiologies, we explored whether children with different cleft subtypes showed distinct epigenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28603561
DOI: 10.1186/s13148-017-0362-2
PMCID: PMC5465456

Genes

CPO
HOXA2
PDGFRA
TBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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