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Article

Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects.

Scientific reports - 26 May 2017

Alvizi Lucas, Ke Xiayi, Brito Luciano Abreu, Seselgyte Rimante, Moore Gudrun E, Stanier Philip, Passos-Bueno Maria Rita

Abstract excerpt

Non-syndromic cleft lip and/or palate (NSCLP) is a common congenital malformation with a multifactorial model of inheritance. Although several at-risk alleles have been identified, they do not completely explain the high heritability. We postulate that epigenetic factors as DNA methylation might contribute to this missing heritability. Using a Methylome-wide association study in a Brazilian cohort (67 NSCLP, 59...

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Identifiers

PMID: 28550290
DOI: 10.1038/s41598-017-02721-0
PMCID: PMC5446392

Genes

CDH1

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