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Article

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

Molecular genetics and genomics : MGG - 23 Jun 2026

Petrin A L, Machado-Paula L A, Keen H L, Hovey L, Doolittle B, Dunlay L, Awotoye W, Xie X J, Zeng E, Butali A, Marazita M L, Murray J C, Moreno-Uribe L M

Abstract excerpt

Understanding how genetic variants influence disease risk through molecular mechanisms remains a central challenge in complex disease genetics. Nonsyndromic orofacial clefts (OFCs) exemplify this challenge, with most risk loci residing in non-coding regions. We hypothesized that common genetic variants influence OFC risk by modulating DNA methylation at regulatory elements through methylation quantitative trait...

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Topics

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Share to Cleft Lip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to CpG Islands

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Share to Epigenesis, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 42334621
DOI: 10.1007/s00438-026-02474-4
PMCID: PMC13290791

Genes

MYC
FOXE1
FRZB
MAFB
NOG
PLCG1
PPM1E
SPRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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