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Article

Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm.

PloS one - 1 Jan 2014

Vazquez-Cintron Edwin J, Vakulenko Maksim, Band Philip A, Stanker Larry H, Johnson Eric A, Ichtchenko Konstantin

Abstract excerpt

We have previously described genetic constructs and expression systems that enable facile production of recombinant derivatives of botulinum neurotoxins (BoNTs) that retain the structural and trafficking properties of wt BoNTs. In this report we describe the properties of one such derivative, BoNT/A ad, which was rendered atoxic by introducing two amino acid mutations to the light chain (LC) of wt BoNT/A, and...

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Identifiers

PMID: 24465585
DOI: 10.1371/journal.pone.0085517
PMCID: PMC3899041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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