Article

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

2017-04-29

Abstract excerpt

The extent to which genetic influences on complex traits and disease are mediated by changes in DNA methylation levels has not been systematically explored. We developed an analytical framework that integrates genetic fine mapping and Mendelian randomization with epigenome-wide association studies to evaluate the causal relationships between methylation levels and 14 cardiovascular disease traits. We identified 10...

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Literature Corpus work: 33963e85-c267-563c-b66e-97e8a5c279ed
DOI: 10.1101/132019

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