Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.

doi:10.1161/CIRCGENETICS.116.001487

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Article

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies.

Circulation. Cardiovascular genetics - 1 Jan 2017

Hedman Åsa K, Mendelson Michael M, Marioni Riccardo E, Gustafsson Stefan, Joehanes Roby, Irvin Marguerite R, Zhi Degui, Sandling Johanna K, Yao Chen, Liu Chunyu, Liang Liming, Huan Tianxiao, McRae Allan F, Demissie Serkalem, Shah Sonia, Starr John M, Cupples L Adrienne, Deloukas Panos, Spector Timothy D, Sundström Johan, Krauss Ronald M, Arnett Donna K, Deary Ian J, Lind Lars, Levy Daniel, Ingelsson Erik

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified loci influencing circulating lipid concentrations in humans; further information on novel contributing genes, pathways, and biology may be gained through studies of epigenetic modifications. METHODS AND RESULTS: To identify epigenetic changes associated with lipid concentrations, we assayed genome-wide DNA methylation at cytosine-guanine dinucleotides...

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PMID: 28213390
DOI: 10.1161/CIRCGENETICS.116.001487
PMCID: PMC5331877

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