Article

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy

2019-07-14

Abstract excerpt

Genetic mutations lead to the production of mutated proteins from which peptides are presented to T cells as cancer neoantigens. Evidence suggests that T cells that target neoantigens are the main mediators of effective cancer immunotherapies. Although algorithms have been used to predict neoantigens, only a minority are immunogenic. The factors that influence neoantigen immunogenicity are not completely understoo...

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Literature Corpus work: 33946956-e9fd-51cb-bb55-6b24ec1eff28
DOI: 10.1101/700732

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