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Article

Characterizing neoantigens for personalized cancer immunotherapy.

Current opinion in immunology - 1 Jun 2017

Capietto Aude-Hélène, Jhunjhunwala Suchit, Delamarre Lélia

Abstract excerpt

Somatic mutations can generate neoantigens that are presented on MHC molecules and drive effective T cells responses against cancer. Mutation load in cancer patients predicts response to immune checkpoint blockade therapy. Additionally, vaccination targeting neoantigens controls established tumor growth in preclinical models. These recent findings led to a renewed interest in the field of cancer vaccines and the...

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Identifiers

PMID: 28478383
DOI: 10.1016/j.coi.2017.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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