Article
Computational prediction of MHC anchor locations guides neoantigen identification and prioritization.
Science immunology - 14 Apr 2023
Xia Huiming, McMichael Joshua, Becker-Hapak Michelle, Onyeador Onyinyechi C, Buchli Rico, McClain Ethan, Pence Patrick, Supabphol Suangson, Richters Megan M, Basu Anamika, Ramirez Cody A, Puig-Saus Cristina, Cotto Kelsy C, Freshour Sharon L, Hundal Jasreet, Kiwala Susanna, Goedegebuure S Peter, Johanns Tanner M, Dunn Gavin P, Ribas Antoni, Miller Christopher A, Gillanders William E, Fehniger Todd A, Griffith Obi L, Griffith Malachi
Abstract excerpt
Neoantigens are tumor-specific peptide sequences resulting from sources such as somatic DNA mutations. Upon loading onto major histocompatibility complex (MHC) molecules, they can trigger recognition by T cells. Accurate neoantigen identification is thus critical for both designing cancer vaccines and predicting response to immunotherapies. Neoantigen identification and prioritization relies on correctly...
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