Neoantigen prioritization based on antigen processing and presentation.

Abstract excerpt

Somatic mutations in tumor cells give rise to mutant proteins, fragments of which are often presented by MHC and serve as neoantigens. Neoantigens are tumor-specific and not expressed in healthy tissues, making them attractive targets for T-cell-based cancer immunotherapy. On the other hand, since most somatic mutations differ from patient to patient, neoantigen-targeted immunotherapy is personalized medicine and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigen Presentation
• Share to Antigens, Neoplasm
• Share to Immunotherapy