Advances and challenges in neoantigen prediction for cancer immunotherapy

Abstract excerpt

Neoantigens, derived from tumor-specific mutations, are promising targets of cancer immunotherapy by eliciting tumor-specific T-cell responses while sparing normal cells. Accurate neoantigen prediction relies on immunogenomics and immunopeptidomics. Immunogenomics identifies tumor-specific mutations via next-generation sequencing. Immunopeptidomics detects MHC-presented peptides using mass spectrometry....

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