Article

Identification of new therapeutic targets in <i>CRLF2-</i> overexpressing B-ALL through discovery of TF-gene regulatory interactions

2019-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Although genetic alterations are initial drivers of disease, aberrantly activated transcriptional regulatory programs are often responsible for the maintenance and progression of cancer. CRLF2 -overexpression in B-ALL patients leads to activation of JAK-STAT, PI3K and ERK/MAPK signaling pathways and is associated with poor outcome. Although inhibitors of these pathways are available, there rema...

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Literature Corpus work: 47061dbf-e88f-5809-ac6c-aff044973a60
DOI: 10.1101/654418

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