Article

Colocalization of expression transcripts with COVID-19 outcomes is rare across cell states, cell types and organs

2023-06-01

Abstract excerpt

Identifying causal genes at GWAS loci can help pinpoint targets for therapeutic interventions. Expression studies can disentangle such loci but signals from expression quantitative trait loci (eQTLs) often fail to colocalize—which means that the genetic control of measured expression is not shared with the genetic control of disease risk. This may be because gene expression is measured in the wrong cell type, phys...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66c994eb-8cf2-5739-a720-602b453f148a
DOI: 10.1101/2023.05.29.23290694

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Colocalization of expression transcripts with COVID-19 outcomes is rare across cell states, cell types and organsDOI 10.1101/2023.05.29.23290694Read

A single-cell genetic colocalization test improves power and resolves disease-mediating cell typesSemantic proximity Read

Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severitySemantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular diseaseSemantic proximity Read

Identification of putative effector genes across the GWAS Catalog using molecular quantitative trait loci from 68 tissues and cell typesSemantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Semantic proximity Read

Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation.Semantic proximity Read

Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes.Semantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell dataSemantic proximity Read

Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations.Semantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease.Semantic proximity Read

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK BiobankSemantic proximity Read

Immune Cell-Based Transcriptomic Mendelian Randomization and Colocalization Study on Type 1 DiabetesSemantic proximity Read