Article

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoids

2025-07-27

Abstract excerpt

<h4>Summary</h4> Down syndrome (DS), due to trisomy 21 (T21), occurs in approximately 14.14 per 10,000 live births in the United States. Reduced neural progenitor cell (NPC) proliferation, delayed neurogenesis, impaired cortical lamination and altered cell fate specification are thought to contribute to cognitive impairments in DS individuals. The molecular mechanisms underlying these deficits are not fully under...

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Literature Corpus work: 5773ccc2-16b6-5fab-9a41-1e19977593fa
DOI: 10.1101/2025.07.26.666926

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