Article

Local adaptation and archaic introgression shape global diversity at human structural variant loci

2021-01-26

Abstract excerpt

Large genomic insertions, deletions, and inversions are a potent source of functional and fitness-altering variation, but are challenging to resolve with short-read DNA sequencing alone. While recent long-read sequencing technologies have greatly expanded the catalog of structural variants (SVs), their costs have so far precluded their application at population scales. Given these limitations, the role of SVs in h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4194f178-e95b-5905-9265-5706e2d26d14
DOI: 10.1101/2021.01.26.428314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local adaptation and archaic introgression shape global diversity at human structural variant lociDOI 10.1101/2021.01.26.428314Read

Local adaptation and archaic introgression shape global diversity at human structural variant loci.Semantic proximity Read

Population Structure, Stratification and Introgression of Human Structural VariationSemantic proximity Read

Population Structure, Stratification, and Introgression of Human Structural Variation.Semantic proximity Read

Deciphering complete archaic introgression sequences in modern human genomesSemantic proximity Read

Similarity-Based Analysis of Allele Frequency Distribution among Multiple Populations Identifies Adaptive Genomic Structural Variants.Semantic proximity Read

A global map for introgressed structural variation and selection in humansSemantic proximity Read

Genetic diversity patterns of human ethnic groups as inferred from the 1000 genomesSemantic proximity Read

Continental-scale genomic analysis suggests shared post-admixture adaptation in the Americas.Semantic proximity Read

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsSemantic proximity Read

Archaic Introgression Shapes Genetic Variation at Loci Associated With DNA Virus Load in Modern Humans.Semantic proximity Read

Signatures of Archaic Adaptive Introgression in Present-Day Human Populations.Semantic proximity Read

<i>MaLAdapt</i> reveals novel targets of adaptive introgression from Neanderthals and Denisovans in worldwide human populationsSemantic proximity Read