Article
Direct evidence of an increasing mutational load in humans
2018-04-25
Abstract excerpt
The extent to which selection has shaped present-day human populations has attracted intense scrutiny, and examples of local adaptations abound. However, the evolutionary trajectory of alleles that, today, are deleterious has received much less attention. To address this question, the genomes of 2,062 individuals, including 1,179 ancient humans, were reanalyzed to assess how frequencies of risk alleles and their h...
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Identifiers and source
- Literature Corpus work
- 28feba5e-7697-5acf-ae04-3d1edf3cc80c
- DOI
- 10.1101/307058