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Article

Population history and natural selection shape patterns of genetic variation in 132 genes.

PLoS biology - 1 Oct 2004

Akey Joshua M, Eberle Michael A, Rieder Mark J, Carlson Christopher S, Shriver Mark D, Nickerson Deborah A, Kruglyak Leonid

Abstract excerpt

Identifying regions of the human genome that have been targets of natural selection will provide important insights into human evolutionary history and may facilitate the identification of complex disease genes. Although the signature that natural selection imparts on DNA sequence variation is difficult to disentangle from the effects of neutral processes such as population demographic history, selective and...

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PMID: 15361935
DOI: 10.1371/journal.pbio.0020286
PMCID: PMC515367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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