Article
Recombination affects allele-specific expression of deleterious variants in human populations.
Science advances - 13 May 2022
Harwood Michelle P, Alves Isabel, Edgington Hilary, Agbessi Mawusse, Bruat Vanessa, Soave David, Lamaze Fabien C, Favé Marie-Julie, Awadalla Philip
Abstract excerpt
How the genetic composition of a population changes through stochastic processes, such as genetic drift, in combination with deterministic processes, such as selection, is critical to understanding how phenotypes vary in space and time. Here, we show how evolutionary forces affecting selection, including recombination and effective population size, drive genomic patterns of allele-specific expression (ASE)....
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