Article

An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations with application to Kaiser GERA cohort

2017-01-19

Abstract excerpt

Simultaneous analysis of genetic associations with multiple phenotypes may reveal shared genetic susceptibility across traits (pleiotropy). For a locus exhibiting overall pleiotropy, it is important to identify which specific traits underlie this association. We propose a Bayesian meta-analysis approach (termed CPBayes) that uses summary-level data across multiple phenotypes to simultaneously measure the evidence...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3327bbe2-e9a4-5f5b-82d1-67759a4d6326
DOI: 10.1101/101543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations with application to Kaiser GERA cohortDOI 10.1101/101543Read

An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations.Semantic proximity Read

Bayesian meta-analysis models for cross cancer genomic investigation of pleiotropic effects using group structure.Semantic proximity Read

Discovering patterns of pleiotropy in genome-wide association studiesSemantic proximity Read

LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies.Semantic proximity Read

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global BiobanksSemantic proximity Read

multi-GPA-Tree: Statistical approach for pleiotropy informed and functional annotation tree guided prioritization of GWAS results.Semantic proximity Read

PleioGRiP: genetic risk prediction with pleiotropy.Semantic proximity Read

A method to map and interpret pleiotropic loci using summary statistics of multiple traitsSemantic proximity Read

Benchmarking of univariate pleiotropy detection methods applied to epilepsy.Semantic proximity Read

Bayesian meta-analysis across genome-wide association studies of diverse phenotypesSemantic proximity Read

A Powerful Method for Pleiotropic Analysis under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate CancerSemantic proximity Read

Inference and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitisSemantic proximity Read