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Article

Bayesian meta-analysis models for cross cancer genomic investigation of pleiotropic effects using group structure.

Statistics in medicine - 15 Mar 2021

Baghfalaki Taban, Sugier Pierre-Emmanuel, Truong Therese, Pettitt Anthony N, Mengersen Kerrie, Liquet Benoit

Abstract excerpt

An increasing number of genome-wide association studies (GWAS) summary statistics is made available to the scientific community. Exploiting these results from multiple phenotypes would permit identification of novel pleiotropic associations. In addition, incorporating prior biological information in GWAS such as group structure information (gene or pathway) has shown some success in classical GWAS approaches....

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PMID: 33368447
DOI: 10.1002/sim.8855

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