Article

PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas

2018-07-25

Abstract excerpt

<h4>Novelty and Impact</h4> The ‘undruggable’ KRas is a prevalent oncogene in CRC with poor prognosis. In hPDAC cells pharmacological targeting of PDEδ affects oncogenic KRas signaling, but it remained unclear whether this approach is transferable to other cancer cells. Here, we show that genetic and pharmacologic PDEδ inhibition also impedes the proliferation of oncogenic, but not wild-type KRas bearing CRC cell...

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Literature Corpus work: 3324d681-623d-5bf4-b816-9a22bda05458
DOI: 10.1101/377259

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