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Article

The KRAS-PDEδ interaction is a therapeutic target.

Cancer discovery - 1 Jul 2013

Abstract excerpt

Targeting the KRAS-PDEδ interaction inhibits KRAS-dependent signaling and tumor growth.

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Topics

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Share to Carcinoma, Pancreatic Ductal
Share to Cyclic Nucleotide Phosphodiesterases, Type 6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23847364
DOI: 10.1158/2159-8290.CD-RW2013-116

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The KRAS-PDEδ interaction is a therapeutic target.PMID 23847364Read ↗

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The KRASG12D inhibitor MRTX1133 elucidates KRAS-mediated oncogenesis.Semantic proximity Read ↗

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A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer.Semantic proximity Read ↗

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.Semantic proximity Read ↗

PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas.Semantic proximity Read ↗

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