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Article

3-Aminoisoquinolines inhibit selectively phosphodiesterase 4B in KRAS-mutated colorectal cancer cell lines in-vitro and in-vivo.

Anti-cancer drugs - 1 Oct 2026

Lapa Gennady B, Tsunoda Toshiyuki, Moiseeva Natalia I

Abstract excerpt

Phosphodiesterase 4B (PDE4B), an isoform of cyclic nucleotide phosphodiesterases, is integrated into cell membranes and hydrolyzes cyclic AMP in specific cellular compartments. Overexpression of PDE4B has been observed in hematological and gastrointestinal tumors harboring KRAS mutations, leading to the disruption of cell cycle regulation. Utilizing molecular docking, we identified 3-aminoisoquinolines as...

Read the complete abstract on PubMed

Topics

Humans
Animals
Cyclic Nucleotide Phosphodiesterases, Type 4
Colorectal Neoplasms
Proto-Oncogene Proteins p21(ras)
Phosphodiesterase 4 Inhibitors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Isoquinolines

Xenograft Model Antitumor Assays

Molecular Docking Simulation

Mutation

Cell Line, Tumor

Antineoplastic Agents

Mice, Nude

Female

Cell Proliferation

Source

Identifiers

PMID: 41934673
DOI: 10.1097/CAD.0000000000001819

Genes

PDE4B
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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