Article
GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines.
International journal of cancer - 1 Jun 2024
Nummela Pirjo, Zafar Sadia, Veikkolainen Erika, Ukkola Iiris, Cinella Vincenzo, Ayo Abiodun, Asghar Muhammad Yasir, Välimäki Niko, Törnquist Kid, Karhu Auli, Laakkonen Pirjo, Aaltonen Lauri A, Ristimäki Ari
Abstract excerpt
Approximately 5% of colorectal cancers (CRCs) have a gain-of-function mutation in the GNAS gene, which leads to the activation of cAMP-dependent signaling pathways and associates with poor prognosis. We investigated the effect of an activating GNAS mutation in CRC cell lines on gene expression and cell proliferation in vitro, and tumor growth in vivo. GNAS-mutated (GNASmt) HCT116 cells showed stimulated synthesis...
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