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Article

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.

Anticancer research - 1 Jul 2017

Nishi Kensuke, Luo Hao, Ishikura Shuhei, Doi Keiko, Iwaihara Yuri, Wills Lauren, Baillie George S, Sakata Toshifumi, Shirasawa Senji, Tsunoda Toshiyuki

Abstract excerpt

BACKGROUND/AIM: We previously reported the crucial roles of oncogenic Kirsten rat sarcoma viral oncogene homologue (KRAS) in inhibiting apoptosis and disrupting cell polarity via the regulation of phosphodiesterase type 4B2 (PDE4B2) expression in human colorectal cancer (CRC) HCT116 cells in a three-dimensional culture (3DC). Here, we evaluated the effects of apremilast, a selective PDE4 inhibitor, on luminal...

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Identifiers

PMID: 28668883
DOI: 10.21873/anticanres.11762

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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