Article

PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties

2022-05-25

Abstract excerpt

Oncogenic KRAS-driven cancers have long been considered as “undruggable” due to limited therapeutic options. While the recent success of KRAS-G12C inhibitors argues against the “undruggability” of KRAS, this treatment only benefits a small proportion of patients with KRAS mutant cancers, leaving an urgent need for modalities to target other KRAS mutants. KRAS-calmodulin (CaM) signaling axis reportedly regulates th...

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Literature Corpus work: a3f1a269-8e58-5cb7-8caf-1bb6fe3dd7e3
DOI: 10.1101/2022.05.24.493257

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