Article

Statin-dye conjugates for selective targeting of <i>KRAS</i> mutant cancer cells

2025-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Over 90% of pancreatic ductal adenocarcinoma (PDAC) patients involve KRAS mutations ( KRAS MUT ), for which current treatment options are limited. Statins, commonly used to lower cholesterol, have demonstrated certain selective toxicity towards KRAS -transformed cells, prompting the question of whether statins could achieve selective uptake specifically in KRAS MUT cells. To investigate this...

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Literature Corpus work: 9bf3ad81-6eb3-51a0-981d-c974a7ee53a6
DOI: 10.1101/2025.06.03.657329

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