Article

PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia

2025-12-24

Abstract excerpt

Loss of the tumor suppressor PTEN is common in T-cell acute lymphoblastic leukemia (T-ALL), and is associated with poor prognosis. PTEN-loss drives robust activation of AKT/mTORC1 signaling to promote leukemic cell growth. We find that PTEN-loss in T-ALL confers dependence on the guanylate nucleotide synthesis enzyme inosine 5’-monophosphate dehydrogenase (IMPDH) for cell growth and viability. This metabolic vulne...

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Literature Corpus work: 3321eb3e-b4fa-5dd7-9f75-dfdaeb1f71fd
DOI: 10.64898/2025.12.22.696045

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